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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MKI67 All Species: 7.27
Human Site: S1451 Identified Species: 22.86
UniProt: P46013 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.43
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46013 NP_001139438.1 3256 358694 S1451 P A A S V T G S K R H P K T K
Chimpanzee Pan troglodytes XP_508147 3257 358658 S1451 P A A S V T G S K R Q P K T K
Rhesus Macaque Macaca mulatta XP_001089669 2126 233775 T468 N K P E K L D T T A G K M C S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus NP_001074586 3177 350846 R1431 I E N L T G L R K Q S R T P K
Rat Rattus norvegicus XP_225460 3119 343332 K1313 T G N S T G H K R R S R A S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421822 2556 283606 S898 R K T K G H F S T G H A E S P
Frog Xenopus laevis NP_001128553 2510 270869 R852 K T P G R R S R K L E T F E I
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782273 1825 188999 T167 P K A P T A T T P K S G A T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 55.1 N.A. N.A. 43.1 43.1 N.A. N.A. 22.4 21.7 N.A. N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 98.7 57.3 N.A. N.A. 58.2 57 N.A. N.A. 38.5 38.1 N.A. N.A. N.A. N.A. N.A. 34.9
P-Site Identity: 100 93.3 0 N.A. N.A. 13.3 20 N.A. N.A. 13.3 6.6 N.A. N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 93.3 6.6 N.A. N.A. 20 33.3 N.A. N.A. 26.6 6.6 N.A. N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 38 0 0 13 0 0 0 13 0 13 25 0 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % C
% Asp: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % D
% Glu: 0 13 0 13 0 0 0 0 0 0 13 0 13 13 0 % E
% Phe: 0 0 0 0 0 0 13 0 0 0 0 0 13 0 0 % F
% Gly: 0 13 0 13 13 25 25 0 0 13 13 13 0 0 0 % G
% His: 0 0 0 0 0 13 13 0 0 0 25 0 0 0 0 % H
% Ile: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % I
% Lys: 13 38 0 13 13 0 0 13 50 13 0 13 25 0 50 % K
% Leu: 0 0 0 13 0 13 13 0 0 13 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % M
% Asn: 13 0 25 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 38 0 25 13 0 0 0 0 13 0 0 25 0 13 13 % P
% Gln: 0 0 0 0 0 0 0 0 0 13 13 0 0 0 0 % Q
% Arg: 13 0 0 0 13 13 0 25 13 38 0 25 0 0 0 % R
% Ser: 0 0 0 38 0 0 13 38 0 0 38 0 0 25 13 % S
% Thr: 13 13 13 0 38 25 13 25 25 0 0 13 13 38 0 % T
% Val: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _